I think in this case, you'll probably want to use a genetic algorithm to generate a topology rather than working on your own. I personally like NEAT (NeuroEvolution of Augmenting Topologies).
The original NEAT paper involves evolving weights for connections, but if you only want a topology, you can use a weighting algorithm instead. You can also mix activation functions if you aren't sure which to use. Here is an example of using backpropagation and multiple neuron types.